Effect of prostaglandin E1 versus corticotomy on orthodontic tooth movement: An in vivo study.

Background and Aim: The aim of the present study is to compare the effect of corticotomy versus prostaglandin E1 injection in human subjects on rate of tooth movement, anchorage loss and their effect on crest bone height and root length. Settings and Design: Clinical interventional study. Split mouth design was used. Materials and Methods: Study was done on 32 regular orthodontic patients. A volume of 100 mcg of prostaglandin E1 was injected on the right side once in 2 weeks and on the left side corticotomy was performed, and canine retraction was started on both sides simultaneously. The rate of space closure and anchorage loss was assessed with casts. The root length and crestal bone height changes were assed with IOPAs. The comparison of rate of tooth movement, anchorage loss, crestal bone height and root length changes between the sides were statistically analyzed using paired t‑test. Results: The average rate of space closure on right side was 0.36 mm/week with a standard deviation of 0.05 mm/week and on the left side average rate of space closure was 0.40 mm/week with a standard deviation of 0.04 mm/week. The difference between the rate of closure between the right side and left where found to be statistically significant (P = 0.003). The anchorage loss, the crestal bone height changes and root length changes were not statistically significant. Conclusion: The rate of tooth movement was significantly more with corticotomies when compared with given dose of prostaglandin injection.

Clinical experience in the use of prostin E2 [Dimoproston] vaginal tablet in obstetric department, Liaquat medical college hospital

Prostaglandins are now widely used in Obstetrics for terminating pregnancy at any stage of gestation. The efficacy and acceptability of protaglandin E and vaginal Tablet was assessed over a period of one year in 120 patients aged 1 4-42 years. The object was to achieve delivery, preferably vaginally. One hundred and ten patients delivered vaginally and 10 needed operative delivery. This preparation was well tolerated with minimum side-effects. The use of Prostin E2 vaginal Tablet is strongly recommended because of its high efficacy, acceptability and minimum patient interference